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The renoprotective effects of benidipine in Chinese senile hypertensive patients
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JPY
Abstract
Objective:This study examines the protective effect of benidipine on the renal function of Chinese senile mild to medium hypertensive patients over a period of 1 year.Methods:Chinese senile mild to medium hypertensive patients were screened and took benidipine for 1 year. Changes in blood pressure, heart rate, serum creatinine, and urinary micro−albumin excretion were compared. Results:After treatment with benidipine alone for 2 weeks, blood pressure was reduced to below the target leve(l 140/90 mmHg)in 6 of the 15 participating patient(s 40%).Diuretics and/or β−receptor blockers were additionally administered to 9 patients. After medication for 8 weeks, 11 patients(73.3%)attained the target blood pressure level. Mean blood pressure was decreased significantly from 151.4/88.4 mmHg before medication to 137.4/81.3 mmHg after medication and remained stable at the designated target level.Serum creatinine was lowered from 78.1±16.9μmol/L before medication to 66.9±15.1μmol/L after 1 year(p=0.02). Urinary micro−albumin was also reduced from 8.28±15.27mg/dL to 1.61±0.93 mg/dL(p=0.055).Conclusions:Benidipine has a stable, long−acting antihypertensive effect and protects renal function.
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