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Effects of Doxapram on Myocardial Repolarization in Anesthetized Rats
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JPY
Abstract
The inhibitory effects of doxapram, a respiratory accelerator, on the cardiac impulseconducting system and myocardial repolarization time were investigated in anesthetized animals using electrocardiography.Doxapram prolonged QT and QTcF, which are indicative of the myocardial repolarization time, in a dose−dependent manner in rats anesthetized by sevoflurane. However,prolongation of the atrioventricular conduction time was not observed, even at the maximum dose(10 mg/kg), and deterioration of either the QT variability index or QT variability ratio,indices of time−dependent variation in cardiac cycle and myocardial repolarization, was not observed. Doxapram prolonged the myocardial repolarization time at high doses, but maintained the physiologically valid QT/RR relationship and did not increase proarrhythmia.
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