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Effects of the 6-Month Cilnidipine Therapyon Urinary 8-iso-Prostanein Essential Hypertensive Patients
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JPY
Abstract
We investigated whether the L/N-type calcium channel blocker, cilnidipine, can influenceoxidative stress by sympathetic nervous system suppression in essential hypertensivepatients. Thirteen patients were treated by cilnidipine for 6 months, and urinary 8-iso-prostane was estimated as oxidative stress marker before and after treatment. Urinaryalbumin excretion(UAE), HOMA-IR and estimated glomerular filtration rate(eGFR)werealso estimated before and after treatment. Systolic and diastolic blood pressures weresignificantly lowered after treatment. UAE and HOMA-IR showed tendency to improveafter treatment(not significant). Estimated GFR significantly improved after cilnidipinetreatment (78±3 mL/min/1.73 m2 to 83±2 mL/min/1.73 m2;p=0.009). And 8-isoprostanewas also significantly lowered after cilnidipine treatment(236.0±47.4 pg/mL to182.2±37.7 pg/mL;p=0.047). Linear regression analysis between BP change and eGFRor urinary 8-iso-prostane changes showed no significant correlations. This suggests thatcilnidipine can ameliorate oxidative stress by suppression of sympathetic nervous system,which is independent of blood pressure lowering.
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