Full text loading...
Therapeutic Research
Abstract
Objectives:Acotiamide hydrochloride hydrate(acotiamide), a drug for the treatment of functional dyspepsia(FD), has been shown to enhance the gastrointestinal motility by inhibiting acetylcholinesterase(AChE) activity. We examined whether acotiamide has a stimulatory effect on duodenal bicarbonate(HCO3-) secretion in rats. Methods:After fasted for 18 h, the animals were anesthetized with urethane. A proximal duodenal loop was perfused with saline, and HCO3- secretion was measured at pH 7.0 by a pH –stat method and by adding 10 mM HCl. Test drugs were administered subcutaneously after the stabilization of basal HCO3-secretion. Results:Acotiamide at doses of 10, 30, and 100 mg/kg significantly increased the duodenal HCO3- secretion in a dose–dependent manner compared with the control group. Likewise, neostigmine bromide, a typical AChE inhibitor, increased the HCO3- secretion, whereas mosapride citrate hydrate(mosapride), a serotonin 5 –HT4 receptor agonist, did not affect the duodenal HCO3- secretion. Conclusions:These results clearly show that acotiamide, but not mosapride, has a stimulatory effect on the duodenal HCO3- secretion in rats. The stimulatory effect of acotiamide on the duodenal HCO3- secretion may contribute to the improvement of meal –related symptoms in patients with FD, in addition to the effect on the gastric prokinetic action.
Data & Media loading...