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薬理と治療
Abstract
Objectives Aqua Q10 P40 is water−soluble type coenzyme Q10 powder, which is dispersed in water, developed by Nisshin Pharma Inc. We investigated the effect of Aqua Q10 P40−containing tablet on physical fatigue in healthy volunteers. Method In a present randomized double−blind, placebo−controlled, crossover trial, 15 healthy volunteers under physical load were randomized to oral Aqua Q10 P40 or placebo administration for 15 days so that no statistical differences in age, gender and body mass index(BMI). Subjects took 4 tablets containing Aqua Q10 P40(180 mg as coenzyme Q10) or 4 placebo tablets per day for 15 days. As a fatigue−inducing physical task, subjects performed workload trials on a cycle ergometer at fixed workloads for 4 hours and then rested for 4 hours. We examined fatigue feeling by visual analogue scale, physical performance by physical working capacity test and autonomic nervous activity by accelerated plethysmography before, during and after physical load. Results Oral Aqua Q10 P40 administration attenuated fatigue feeling and inhibited the decrease in physical performance and improved the imbalance of autonomic nervous activity by physical load. Conclusion These results suggest Aqua Q10 P40 has the effect of attenuating fatigue and Aqua Q10 P40−containing tablet is one of the promising candidates for anti−fatigue food. (Jpn Pharmacol Ther 2008;36:141−52)KEY WORDS Coenzyme Q10, Fatigue, Visual analogue scale, Physical performance, Accelerated plethysmography
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