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薬理と治療
Abstract
Objectives CBEX−Dr is a chicken breast extract containing imidazole dipeptides by Nippon Meat Packers, Inc. We investigated the safety of long−term administration of CBEX−Dr−containing drink in a parallel, randomized, double−blind and placebo−controlled study. Methods Forty−eight healthy subjects(24 females, 24 males, age 39.6±8.2 years old)were randomized in two groups so that there were no statistical differences in age, gender, body mass index(BMI)or visual analogue scale(VAS)score. The subjects took CBEX−Dr(imidazole dipeptides 400 mg)−containing drink or placebo once a day for 12 weeks. Results No adverse events which attributed to CBEX−Dr−containing drink were observed in results of blood examination, urinalysis, physical examination or careful evaluation by doctor. Moreover, CBEX−Dr−containing drink attenuated fatigue sensation. Conclusions Our present observations demonstrated the safety of long−term administration of CBEX−Dr−containing drink in healthy subjects.(Jpn Pharmacol Ther 2008;36:213−24)KEY WORDS CBEX−Dr, Imidazole dipeptide, Fatigue, Safety, Visual analogue scale
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