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健常者を対象とした CBEX−Dr 配合飲料の過剰摂取における安全性
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JPY
Abstract
Objectives CBEX−Dr is a chicken breast extract containing imidazole dipeptides by Nippon Meat Packers, Inc. We investigated the safety of excess administration of CBEX−Dr−containing drink in a parallel, randomized, double−blind and placebo−controlled study. Methods Forty−eight healthy subjects(24 females, 24 males, age 39.6±8.2 years old)were randomized in two groups so that there were no statistical differences in age, gender or body mass index(BMI). The subjects took CBEX−Dr(imidazole dipeptides 1200 mg)−containing drink or placebo once a day for 4 weeks. Results No adverse events which attributed to CBEX−Dr−containing drink were observed in results of blood examination, urinalysis, physical examination or careful evaluation by doctor. Conclusions Our present observations demonstrated the safety of excess administration of CBEX−Dr−containing drink in healthy subjects.(Jpn Pharmacol Ther 2008;36:225−35) KEY WORDS CBEX−Dr, Imidazole dipeptide, Excess administration, Safety
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