薬理と治療

Abstract

[Objectives We describe our practice of negative pressure wound therapy and the effects of this method combined with treatment using a basic fibroblast growth factor （bFGF） preparation. Methods After adequate debridement, the wound was sealed with a dressing, and continuous suction of the closed cavity was performed using a silicon tube（4 mm in diameter）. The suction pressure was−125 mmHg but reduced in the presence of pain. After good wound bed preparation, bFGF was used. The device was replaced at 3−day intervals. Results & Conclusions In all patients, negative pressure wound therapy combined with bFGF treatment had potentiation effects. Since appropriate wound bed preparation by negative pressure wound therapy enhanced the activity of various growth factors and receptors, bFGF could be effectively used. This combination therapy may also be indicated in patients who do not respond to bFGF alone or those at risk of delayed healing, such as in the case of malnutrition due to underlying disease.（Jpn Pharmacol Ther 2008；36：325−31） KEY WORDS Basic fibroblast growth factor（bFGF）, Wound bed preparation, Pressure ulcer, Vacuum−assisted closure, Objectives We describe our practice of negative pressure wound therapy and the effects of this method combined with treatment using a basic fibroblast growth factor （bFGF） preparation. Methods After adequate debridement, the wound was sealed with a dressing, and continuous suction of the closed cavity was performed using a silicon tube（4 mm in diameter）. The suction pressure was−125 mmHg but reduced in the presence of pain. After good wound bed preparation, bFGF was used. The device was replaced at 3−day intervals. Results & Conclusions In all patients, negative pressure wound therapy combined with bFGF treatment had potentiation effects. Since appropriate wound bed preparation by negative pressure wound therapy enhanced the activity of various growth factors and receptors, bFGF could be effectively used. This combination therapy may also be indicated in patients who do not respond to bFGF alone or those at risk of delayed healing, such as in the case of malnutrition due to underlying disease.（Jpn Pharmacol Ther 2008；36：325−31） KEY WORDS Basic fibroblast growth factor（bFGF）, Wound bed preparation, Pressure ulcer, Vacuum−assisted closure]