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薬理と治療
Abstract
Acetic acid and γ−Aminobutyric acid(GABA)are known that they both have hypotensive effect through different mechanisms. We investigated the effect of brown rice vinegar (unpolished rice vinegar)with high concentration of GABA, on blood pressure levels and its safety. A randomized double blind, placebo−controlled study was conducted on 71 subjects (average age:47.4±10.4, male:24, female:47)with mild hypertenion without treatment. The subjects were divided into three groups;placebo group, brown rice vinegar(with few GABA)group, brown rice vinegar with high concentration of GABA group. Subjects were given 7.5 mL of each drink per day for 12 weeks. Brown rice vinegar group took about 250 mg of acetic acid per day, and brown rice vinegar with high concentration of GABA group took about 270 mg of acetic acid and 15 mg of GABA. As a result, both brown rice vinegar with and without high concentration of GABA had significantly lower blood pressure than placebo. But, there was no significant difference in blood pressure between brown rice vinegar with and without high concentration of GABA. Therefore we could not clarify the primacy of brown rice vinegar with high concentration of GABA over brown rice vinegar on hypotensive effect. Also, the administration of the test diets for 12 weeks showed no adverse reactions in blood tests, urine tests and physical examinations. These results suggested that the brown rice vinegar with high concentration of GABA is useful for controlling blood pressure in mild hypertensive subjects without any adverse effects, as well as brown rice vinegar(with few GABA).(Jpn Pharmacol Ther 2008;36:429−44)KEY WORDS Vinegar, Acetic Acid, γ−Aminobutyric acid(GABA), Hypertension
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