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薬理と治療
Abstract
Osaka Association of General Physician established the“Osaka Life−style Related Diseases Prevention Network” to investigate the efficacy and safety of functional foods in patients. We have currently focused on constipation, which is general disorder in clinical practice, and conducted a study. The subjects were 132 men and women aged 20 to 70 years with constipation and abdominal disorder. The subjects were instructed to take a commercially available yogurt including Bifidobacterium lactis DN−173 010 for approximately 2 weeks and the states of constipation and abdominal disorder before and after consumption were investigated. The results revealed that there were greater improvements including increased stool frequency and softness and decreased abdominal pain and discomfort after consumption than before consumption. For the safety, 3 adverse events that could be related to the test food occurred in 3 out of 117 subjects who were analyzed for safety. All of these events were minimal and were less likely to be related to the test food. There was no interaction with specific drugs. These results indicate that the yogurt containing B. lactis DN−173 010 was effective in patients with constipation and abdominal disorder, has high safety in combination with pharmaceutical agents, and is useful in clinical practice. (Jpn Pharmacol Ther 2008;36:501−7)KEY WORDS Bifidobacterium lactis DN−173 010, Constipation, Abdominal pain and discomfort
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