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薬理と治療
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Abstract
Recently, pain control therapy is actively started with chemotherapy. Fentanyl has been demonstrated to have high analgesic efficacy and cause less gastrointestinal disturbance. Fentanyl patches require only replacement every 72 hours so they are expected to improve QOL of patients suffering from cancer pain. However, there are several clinical reports that the analgesic effect of the patches can not be sustained or maintain a steady state of pain control. In this study, we focused on the relation between skin condition, especially dry skin and drug absorption. By measuring Transepidermal Water Loss(TEWL), we established a dry skin rat model treatment with silica−gel. Applying fentanyl a patch on this model, serum fentanyl concentration of dry skin rat was significantly inhibited compared with that of control. In this study, by optimizing the narcotics patches used, we conclude the importance of prevention of skin drying. Thus, it is significant for pharmacists not only to purchase, administer and prepare them but also to apply them to patients in light of their skin condition using aids like TEWL. As a result, patients may be relieved of pain.(Jpn Pharmacol Ther 2008;36:589−92)KEY WORDS Fentanyl patch, Dry skin, TEWL, Pain control
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