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薬理と治療
- Author: 鈴木研一1
Abstract
Objectives To examine the effects of single−dose administration of wheat albumin(WA)on postprandial blood glucose control. Method A randomized single−blind, placebo−controlled, crossover trial was conducted in 17 volunteers with slightly higher fasting blood glucose. The volunteers were randomly assigned to WA group or placebo group. The volunteers of each group were orally administered 0.5 g of WA or placebo respectively in hard capsule forms together with the calorie controlled breakfast. We monitored postprandial blood glucose level after they took the breakfast. Results The postprandial blood glucose levels for WA and placebo group peaked at one hour after taking WA and placebo. The peaked values of WA group was significantly lower than that of placebo group. In addition, the increased value of WA group for the peaked blood glucose level was 19% lower than that of placebo group(p<0.01). The AUC of the blood glucose levels up to 3 h after WA intake were 15%(p<0.05)lower than that of the placebo group. For the subjects of the fasting blood glucose were not more than 126 mg/dL, the peaked postprandial blood glucose value were significantly decreased by the intake of WA and increased value was decreased 18%(p<0.05)compared with placebo group. Although the AUC of blood glucose levels up to 3 h after WA intake were 14% lower than that of the placebo group, this was not significant. In the present study, subjective symptoms, objective symptoms, physiological test findings and clinical laboratory test findings did not indicate any undesirable symptoms resulting from consumption of the test food of WA.Conclusion The test foods, 0.5 g of WA, significantly decreased the postprandial blood glucose level for the subjects of the fasting blood glucose were 110−140 mg/dL. In addition, for the subjects of the fasting blood glucose were 110−126 mg/dL, the test food, 0.5 g WA, also decreased the postprandial blood glucose significantly. Therefore WA is considered to be useful, for the people who have higher blood glucose, to control their blood glucose level.(Jpn Pharmacol Ther 2008;36:761−5)KEY WORDS Wheat albumin, α−amylase inhibitor, Postprandial blood glucose
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