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薬理と治療
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Abstract
It has been reported that green tea extract(GTE)reduces body fat accumulation in several clinical trials;however, impacts of decaffeinated GTE on body fat and metabolic disorders in humans are unknown. We investigated whether daily consumption of decaffeinated GTE ameliorates body weight, waist circumference, abdominal body fat, blood lipids and safety parameters in overweight and obese adults. This is a randomized, double−blind, placebo− controlled, and parallel study. After a 2−week run in period, 81 healthy Japanese overweight and obese men(BMI≧25)were randomly assigned to one of two groups, who consumed 1 bottle sports drink/day containing decaffeinated GTE(548 mg tea catechins and 0mg caffeine:catechin group, n=40), or 1 bottle sports drink/day(0 mg of both tea catechins and caffeine:placebo group, n=41)over 12 weeks. At the end of the study, body weight, waist circumference, and body fat including visceral fat area(VFA)were significantly lowered in the catechin group than in the placebo group. In addition, in the present study, cholesterollowering effects were found in the catechin group. In conclusion, daily consumption of a drink enriched with tea catechins, even with no caffeine, may be useful for the primary prevention of metabolic syndrome and atherosclerotic diseases in obese population.(Jpn Pharmacol Ther 2008;36:767−76)KEY WORDS Green tea, Catechins, Caffeine, Obesity, Cholesterol, LDL, Human
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