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薬理と治療
Abstract
We have investigated the safety on excess intake of the milk−coffee, which has an antihypertensive effect of chlorogenic acids made by reduced oxidative component, in a randomized, single−blind, placebo−controlled, parallel study. Ordinary commercially available canned coffee was used as a control beverage. The subjects were 37 adult women and men(19 in the test beverage group, 18 in the control beverage group)with blood pressures ranging from optimal to mild hypertension, none of who were taking medication. The subjects in the test beverage group were given three cans of the anti−hypertensive test beverage(570 g)and the subjects in the control beverage group were given the same amount of ordinary canned coffees per day for 4 weeks. The subjects were instructed to consume either the test beverage or the control beverage all at once as often as possible. Although several subjects who drank three cans of test or control beverage all at once complained of abdominal symptoms such as diarrhea and heartburn, there were no significant differences between groups in the number of subjects in each symptom. These symptoms were transitory and not serious. Blood pressure and blood laboratory tests showed no abnormal changes of clinical importance. These results suggest that the anti−hypertensive milk−coffee can be safely consumed similar to ordinary canned coffee.(Jpn Pharmacol Ther 2008;36:825−33)KEY WORDS Anti−hypertensive beverage, Chlorogenic acids, Excess intake, Safety evaluation
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