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薬理と治療
Abstract
Objectives The purpose of this study was to evaluate the skin permeability and analgesic/anti−inflammatory effects of a ketoprofen−containing tape and a loxoprofen sodium−containingtape.Methods For measurement of the skin permeability, skin specimens from hairless micewere mounted on the diffusion cells, and then, the receptor solution was collected every 2hours for 24 hours. The pharmacological effects of the both products were evaluated usingrat models of yeast−induced hyperalgesia, as an acute inflammation model, and, adjuvantinducedarthritis(AA)and collagen−induced arthritis(CIA), as chronic inflammation models,respectively. For yeast−induced hyperalgesia rats, the tapes were applied 1 hour or 3 hoursafter the injection of yeast, and for AA and CIA rats, those were applied for 24 hours a dayfor 7 days continuously after the induction of arthritis.Results In the skin permeability study, the cumulative amount of ketoprofen was higherthan those of loxoprofen and trans−OH loxoprofen. In the pharmacological studies, the bothproducts attenuated decrease of the paw−withdrawal threshold and increase of the paw swellingrate in each models. Moreover, the effects of the ketoprofen−containing tape were comparableto, or stronger than those of the loxoprofen sodium−containing tape.Conclusions These results suggest that the ketoprofen−containing tape and the loxoprofensodium−containing tape have analgesic and anti−inflammatory effects, and pharmacologicaleffects of the ketoprofen−containing tape are thought to be comparable to, or stronger thanthose of the loxoprofen sodium−containing tape. The ketoprofen−containing tape may be, atleast in part, more useful for inflammatory disorders with superior pharmacological efficacies,because of the higher skin permeability.(Jpn Pharmacol Ther 2008;36:1123−9)KEY WORDS Ketoprofen−containing tape, Loxoprofen sodium−containing tape, Skin permeability,Analgesic, Anti−inflammatory
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