薬理と治療

Abstract

To evaluate effects of glucosyl hesperidin−containing food on body weight and serum triglyceridelevels, a randomized, placebo−controlled, double−blind parallel group study wasconducted. The subjects were 93 non−lean［19 kg／m2≦body mass index（BMI）＜30 kg／m2］and mildly hypertriglyceridemic（serum triglyceride≧120 mg／dL）adult volunteers consistingof 70 males and 23 females（average BMI：24.5±2.2 kg／m2, average triglyceride：181.4±60.5 mg／dL）. Subjects were randomly divided into four groups：low dose group（250 mg／dayglucosyl hesperidin）, medium dose group（500 mg／day）, high dose group（1000 mg／day）andplacebo group. Each group was given appropriate amount of glucosyl hesperidin everyday for4 weeks. The result revealed that the body weight and body mass index（BMI）were significantlylowered in medium dose group（Abody weight；−0.59±0.93 kg（p＜0.05）, ABMI；−0.20±0.31 kg／m2（p＜0.05）respectively at 4 weeks）compared to the values at 0 week. Thesignificant decrease of the body weight and BMI were also seen in high dose group. Also, thewaist circumference was significantly lowered or tended to be reduced in medium dose group（A−1.73±3.26 cm（p＜0.1）at 2 weeks and A−2.30±3.79 cm（p＜0.05）at 4 weeks）. Theserum triglyceride levels showed no change in each group during the test period. No clinicallysignificant adverse events were observed in association with the intake of the testfoods. Thus the present observations suggest that the consecutive daily intake of glucosylhesperidin at 500 mg or more may reduce body weight in non−lean subjects.（Jpn Pharmacol Ther 2008；36：1141−58）KEY WORDS Glucosyl hesperidin, Body weight, Waist circumference, Triglyceride