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薬理と治療
Abstract
A double−blind crossover clinical study was conducted on 50 adults with mild constipationto examine the effects of AOJIRU drink powder of Angelica keiskei leaf containing indigestibledextrin on defecation. The subjects were mean age of 37.0±6.9 years. Each subjectwas given either AOJIRU drink powder of Angelica keiskei leaf containing indigestible dextrin(test drink)or placebo drink, 3 times a day for 2 weeks. The test drink contains 5.1 g of indigestibledextrin per day amount, while the placebo drink contains maltodextrin instead. As aresult, the subjects taking the test drink showed a significant increase in the defecation frequencyand the estimated fecal quantity compared to those taking the placebo drink(p<0.05). It was also confirmed that the test drink does not cause any adverse events. In conclusion,the administration of AOJIRU drink powder of Angelica keiskei leaf containing indigestibledextrin serves for improving the defecation in adults with mild constipation.(Jpn Pharmacol Ther 2008;36:1159−65)KEY WORDS AOJIRU drink powder of Angelica keiskei leaf,Indigestible dextrin,Defecationfrequency,Estimated fecal quantity
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