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薬理と治療
Abstract
Vitamin K is one of the nutritional elements which promote bone formation, and it is recommendedto take vitamin K to prevent osteoporosis. We evaluated the efficacy in bonemetabolism and safety of 12 weeks intake of vitamin K2(menaquinone−4:MK−4)containingcalcium tablets.Eighty−six healthy male and female volunteers were divided into two groups;onegroup took calcium tablets and the other group took vitamin K2 (MK−4)(1.5 mg/day)containingcalcium tablets for 12 weeks. In the vitamin K2(MK−4)containing calcium tablets takinggroup, γ−carboxylated osteocalcin(GlaOC)was increased and undercarboxylated osteocalcin(ucOC)was decreased in both female(before and after menopause)and male subjects, suggestingpromoted bone formation by vitamin K2(MK−4). There were no adverse events orclinically relevant changes in safety parameters during the 12 weeks of intake and follow−upperiod of successive 4 weeks.This study showed that the vitamin K2(MK−4)containing calcium tablets used in thisstudy is effective in improving bone metabolism safely, and is effective in preventing osteoporosis.(Jpn Pharmacol Ther 2008;36:1179−88)KEY WORDS Vitamin K2,Calcium,Osteocalcin,Bone formation,Osteoprosis
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