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ビタミン K2(メナキノン−4)添加カルシウム錠菓の過剰摂取による安全性の検証
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JPY
Abstract
Vitamin K is known as a nutrient to promote bone formation, and there are some foodproducts containing vitamin K2 which have been designated as FOSHU. We evaluated the biologicaleffects of excess intake of a new product, vitamin K2(menaquinone−4:MK−4)containingcalcium tablets, for 4 weeks.Twenty healthy male and female volunteers, aged 20 to 69, took 5 times as much as recommendedamount calcium tablets with 7.5 mg of vitamin K2(30 tablets, 7.5 g). γ−Carboxylatedosteocalcin(GlaOC)was increased and undercarboxylated osteocalcin(ucOC)wasdecreased after 4 weeks administration. These results suggested that vitamin K2(MK−4)promotes bone formation. Furthermore, there were no adverse events or clinical changes insafety parameters relevant to the product during 4 weeks of period. This study proves thesafety of excess intake of a new product, vitamin K2(MK−4)−containing calcium tablets.(Jpn Pharmacol Ther 2008;36:1189−95)KEY WORDS Vitamin K2,Calcium,Osteocalcin,Bone formation,Excess intake
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