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薬理と治療
Abstract
Clindamycin(JP, USP)is an effectual antibiotics for gram−positive coccus, anaerobes ormycoplasma genus. In the case of intractable infection caused by anaerobes such as peptococcusgenus or bacteroides genus, clindamycin injections are useful for the combination treatmentwith β lactam antibiotics, which is recommended by the academy guidelines for infectioncontrol.In Japan, there are the brand−name medicine which is sold by Pfizer and five genericmedicines.In Japan, based on the agreement of listing additives of ethical drugs which was formedby the Japan Pharmaceutical Manufacturers Association, JPMA(No. 712 reports of the 1st ofOct.. 2001), the name of all additives must be written on the package insert except for isotonicagents, water for injection and pH adjustments such as HCl or NaOH solution. Accordingto the package insert, most of Clindamycin injections sold in Japan contain only benzylalcoholas preservative. But there are some preparations of clindamycin injection added otherpreservatives above mentioned. One is citrate in Japanese preparations, the other is EDTA inUS products.Clindamycin injections should be stored at room temperature and they are valid for twoyears. We examined the survival rate of clindamycin to consider whether the additives withthe complex agent mentioned above are necessary or not for the stability of the component.It is confirmed that the clindamycin injections get deteriorated with severe conditionsuch as high temperature during the distribution from a wholesale dealer to a hospital by caron a hot summer day.(Jpn Pharmacol Ther 2009;37:109−13)KEY WORDS Clindamycin, Additives, Preservatives, Cirate EDTA
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