薬理と治療

Abstract

Objectives Obesity is one of the most important worldwide health problems. We investigatedthe effects of quercetin glucosides, which is enzymatically trans−glycosylated isoquercitrinfrom natural resources, on visceral fat weight in diet−induced obese mice and in vitro3T3−L1 adipocytes.Methods Glycerol release and phosphorylation of hormone sensitive lipase（HSL）wereevaluated in differentiated 3T3−L1 adipocytes. In diet−induced obesity model, mice were feddiets containing 0, 0.05 and 0.25％（w／w）quercetin glucosides for 3 months.Results In 3T3−L1 adipocytes, quercetin accelerated the glycerol release and phosphorylationof HSL in dose−dependent manner. Supplementation of quercetin glucosides in dietinducedobese mice resulted in reduced body weight gain, and significant reduction of visceralfat weight and adipocyte hypertrophy.Conclusions These results suggested that the quercetin glucosides activate lipolytic passwayin adipose tissues and this compound is beneficial to prevent and improve obesity.（Jpn Pharmacol Ther 2009；37：123−31）KEY WORDS Polyphenol，Quercetin，quercetin glucoside，Diet−induced obesity，Lipolysis