薬理と治療

Abstract

The salmon peptide digested from salmon muscle showed a strong angiotensinI−convertingenzyme inhibitory activity, and blood pressure reducing effect in spontaneous hypertensiverats. Previously, we reported about the significant blood pressure control effect ofsalmon peptide in subjects with high−normal blood pressure and mild hypertension in thelong−term human clinical trials.In order to evaluate the dose−dependency anti−hypertensive effect of salmon peptide, arandomized, double−blind, placebo−controlled trial was conducted on 76 high−normal bloodpressure or mild hypertensive subjects. The subjects were divided into four groups beforethe study and there were no statistical differences in sex, age, systolic blood pressure and diastolicblood pressure. The test food groups were given a drink containing 1, 2 or 4 g ofsalmon peptide, respectively, for 4 weeks and the placebo group was given a drink containingno salmon peptide during the same period of time.The results showed the dose−dependent anti−hypertensive effect due to salmon peptideintake distinctly from 0 to 4 g, and the significant differences were observed in systolic bloodpressure of the 2 and 4 g intake groups at the 4th week.（Jpn Pharmacol Ther 2009；37：133−43）KEY WORDS Salmon peptide, Blood pressure, AngiotensinI−converting enzyme inhibitor,Dose−dependency