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Toxicity of PG2K20 for 28 Days Administration in Rats
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JPY
Abstract
We examined the toxicity of PG2K20, γ−aminobutyric acid produced by fermentationfor 28 days administration in rats. We found no remarkable difference in growth, daily intakeof feed and water in both group and no abnormal findings in health condition. In the histopathologicaltest, fatty degeneration in the liver cell was simple one and other findings were allat low levels. The numeric value of the liver function and kidney function from histopathologicaltest do not connected to these findings. The testis weight of testing rats was significantlyheavier than that of control, however, this difference is within the limit of normal weight andno abnormal finding was recognized in histopathological test.(Jpn Pharmacol Ther 2009;37:173−9)KEY WORDS γ−aminobutyric acid,GABA,Toxicity
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