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薬理と治療
Abstract
Objectives Henshikou is a crude OTC drug for gastrointestinal complaints. To establish itspharmacological profile, several tests using rats and mice were conducted.Methods Effects on alcohol dehydrogenase activity and heme oxygenase−1 induction werestudied in vitro. Effects on blood ethanol level after oral administration of ethanol, gastriclesion induced by ethanol, restraint and water−immersion stress, experimental reflux esophagitisand dextran sulfate induced colitis were studied in vivo using rats and mice.Results Henshikou showed lowering effect of blood ethanol level after oral administrationof ethanol, and protective effect on the injury model of esophagus, gust and colon in rats ormice by oral administration. The effective doses were not apart from that for humans. Thisdrug also showed anti−inflammatory effect in mice and increased heme oxygenase−1 level incultured Hep G2 cells.Conclusions Above results suggest that Henshikou, as an OTC drug for gastrointestinalcomplaints, is effective for reducing ethanol toxicity and protection of gastrointestinal mucosa.(Jpn Pharmacol Ther 2009;37:197−208)KEY WORDS Ethanol disposition, Peptic ulcer, Colitis, Heme oxygenase−1
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