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ヤーコン葉・茎エキス配合食品の長期反復摂取時における安全性および食後血糖上昇抑制効果の減弱性の検討
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JPY
Abstract
To evaluate the safety of long−term repeated intake of food containing extract from leafand stem of yacon and the possible attenuation in its inhibitory effect on the postprandial elevationin blood glucose, we conducted a randomized, double−blind, placebo−controlled, parallel−group study on 48 male and female with a fasting blood glucose level of less than 140mg/dL.The subjects in the test food group consumed a test meal containing 900 mg of extractfrom yacon leaf and stem three times a day for 12 weeks, but no adverse events attributableto its repeated ingestion were detected. Furthermore, in the meal challenge test with foodcontaining extract from yacon leaf and stem conducted immediately after 12 weeks of continuousintake, no significant differences in the postprandial rise in blood glucose were notedbetween the test food and control groups, indicating that the inhibitory effect of the test foodon the postprandial elevation in blood glucose was not attenuated.These results demonstrate that food containing extract from yacon leaf and stem ishighly safe for long−term repeated consumption and exhibits enduring medium−and longtermeffectiveness in inhibiting the postprandial elevation of blood glucose.(Jpn Pharmacol Ther 2009;37:265−75)KEY WORDS Yacon, Safety, Attenuation effect, Postprandial blood glucose, Diabetes mellitus
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