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薬理と治療
Abstract
Background Several studies in rodents and humans reported that oxidation rate of dietarydiacylglycerol(DAG)was greater significantly than that of dietary control triacylglycerol(TAG). And it may be one of the mechanisms underlying the suppressive effect of DAG onbody fat accumulation. In this present study, it was investigated that effect of single oraladministration of DAG or TAG on postprandial oxidation of concomitant dietary fat.Methods Double−blind cross over designed study was conducted in 10 healthy subjects.The test meals were prepared based on the sleeping metabolic rate(energy, 635.7±69.5kcal;dose of the test oil(DAG or TAG), 10.1±1.1 g, mean±standard deviation). And theboth DAG and TAG meals were added 0.9 g of 13C labeled−triolein(13C−triolein)as tracer ofconcomitant dietary fat.Results Recovery rate of 13CO2 in breath after DAG meal were greater significantly thanthat after TAG meal, suggesting that dietary DAG stimulated postprandial oxidation of concomitantdietary fat. Whole body energy expenditure and respiratory quotient(RQ)were notsignificantly different. Postprandial serum triglyceride level was significantly lower after DAGmeal than that after TAG meal observed as several previous studies.Conclusion It was suggested that DAG enhanced postprandial oxidation of concomitant dietaryfat and it may support the suppressive effect of DAG on body fat accumulation.(Jpn Pharmacol Ther 2009;37:423−31)KEY WORDS Diacylglycerol, Triacylglycerol, Dietary fat oxidation, Energy expenditure,Respiratory quotient
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