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薬理と治療
Abstract
There is little information about the effects of narcotics on the sleep−wake rhythm inrodents, though it is well known that the drugs have several central side effects. The presentstudy was undertaken to investigate the characteristics of narcotics in rat sleep patterns.Electrodes were chronically implanted into the cortex and dorsal neck muscle of rats for electroencephalogram(EEG)and electromyogram(EMG)recordings, respectively. EEG and EMGwere recorded with an electroencephalograph. SleepSigh ver. 2.0 was used to analyse thesleep−wake state. Total times of wakefulness, non−rapid eye movement(NREM)sleep andrapid eye movement(REM)sleep were measured from 10:00 to 16:00. Morphine at doseof 10 mg/kg caused a significant decrease in sleep latency and total REM sleep time, thoughno significant effects were observed in total awake and NREM sleep times. On the otherhand, fentanyl caused no significant effect on sleep latency and total times of wakefulness,NREM sleep and REM sleep. Oxycodone at a dose of 3 mg/kg caused a significant decreasein sleep latency, although the drug showed no influence on total wake, NREM sleep andREM sleep times. From these findings, it can be concluded that morphine and oxycodonecaused somnolence, while fentanyl showed no influence on the sleep−wake rhythm in rats.(Jpn Pharmacol Ther 2009;37:643−7)KEY WORDS Morphine,Fentanyl,Oxycodone,Sleep−wake rhythm
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