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薬理と治療
Abstract
We investigated the effects of the chewing gum containing phosphoryl oligosaccharidesof calcium(POs−Ca(+)gum)on recovery of mineral contents(remineralization)and crystalcontents(recrystallization)of early enamel lesion of bovine teeth in 8 adult volunteers. Theeffect of POs−Ca was assessed under double blind crossover design. The volunteers wereequally divided into two groups, and chewed the gum once a day, for 5 days. The durationtime of each chewing was 20 minutes, and whole saliva secreted from each volunteer wascollected. Then, the enamel slabs, which were demineralized in advance, were immersed inthe saliva. In this step, we designed each slab to have three regions:the sound, demineralized,and remineralized. The remineralization effect of POs−Ca was assessed from the mineralloss parameters from the transversal microradiography analyses after immersion of theslabs. In addition, the recrystallization effect of POs−Ca was assessed from the quantitativeanalyses of the hydroxyapatite crystals in the remineralized region with 6μm X−raymicrobeam. The recrystallization degree was scanned from the serial 5μm spots aligned fromthe enamel surface to dentin of each region of the enamel slabs. As a result, both the remineralizationand recrystallization effect on the bovine enamel of the POs−Ca(+)gum wasobserved significantly(p<0.05)in comparison with that of the POs−Ca(−)gum. Theseresults indicate that chewing of POs−Ca(+)gum could be one effective approach to facilitateboth remineralization and recrystallization of early−stage dental caries and thereby to maintainteeth sound and healthy.(Jpn Pharmacol Ther 2009;37:849−56)KEY WORDS POs−Ca, Enamel, Remineralization, Recrystallization, Chewing gum
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