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薬理と治療
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Abstract
Background In recent years, hyaluronic acid has been developed that can be edible, andingested orally as a dietary supplement that has been reported to the effect of knee pain andother degenerative knee joint disease. However, reports on the safety of oral intake is notneed to consider.Objectives A placebo−controlled, double−blind study was performed to assess the safety ofexcessive intake of tablets containing hyaluronic acid in normal healthy adults.Methods They were divided into three groups:placebo group(age 37.5±15.4 y.o.), highdosegroup(intake of 24 tablets/day, age 37.8±13.6 y.o.)and standard−dose group(intake of8 tablets/day, age 37.6±11.2 y.o.). They were given for 4 weeks. We examined at blood pressuremeasurement, physical examinations, blood test, urinalysis and interview before the trial,then 2 and 4 weeks after the start of the trial, and 2 weeks after 4 weeks intakes.Results Blood pressure, body composition, hematologic and biochemical tests in the blood,which showed some minor variations, was the change in the threshold.Conclusions The results demonstrated the safety of excess−intake of tablets containinghyaluronic acid because there were no changes to clinical problems in each test.(Jpn Pharmacol Ther 2009;37:953−61)KEY WORDS Tablets containing hyaluronic acid, Excess−intake, Safety
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