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薬理と治療
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Abstract
Donepezil hydrochloride OD Tablets 5 mg「Nichi-Iko」(Nichi-Iko Pharmaceutical Co.,Ltd.;Donepezil OD)and Donepezil hydrochloride F. G. 0.5%「Nichi-Iko」(Nichi-Iko Pharmaceutical Co., Ltd.;Donepezil FG)are developed by Nichi-Iko Pharmaceutical Co., Ltd. as generic drugs of Aricept D Tablets 5 mg(Eisai Co., Ltd.;Aricept D)and Aricept Fine Granules 0.5%(Eisai Co., Ltd.;Aricept FG), respectively, which are used for treatment of Alzheimer’s dementia. The improving effects for learning and memory deficit of these preparations on scopolamine-induced amnesia model in rats were studied in comparison with original drugs using an eight-arm radial maze task. The improving effects were evaluated with four endpoints, the number of working memory error, the running distance and time, and the rate of true choice. Scopolamine injection exhibited a significant increase in the number of working memory error, a significant prolongation of the running time and distance, and a significant decrease in the rate of true choice to confirm the induction of amnesia. Donepezil OD or Aricept D administration showed significant improving effects for learning and memory deficit on the scopolamine-induced amnesia model in all endpoints, and its efficacy of both drugs are comparable. Donepezil FG or Aricept FG administration also showed significant improving effects for learning and memory deficit on the scopolamine-induced amnesia model in all endpoints, and its efficacy of both drugs are comparable. These results suggest that Donepezil OD and Donepezil FG improved learning and memory deficit of the scopolamine-induced amnesia model and its efficacy is equal to Aricept D and Aricept FG, respectively.
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