薬理と治療

Abstract

Objectives　Residual alcohol effects on physiological and psychological symptoms are commonly experienced the next morning after alcohol consumption. The purpose of this study was to assess the efficacy of L－ornithine－L－aspartate（a stable salt of L－ornithine and Laspartate；LOLA）on alcohol－induced mood states observed the next morning. Methods　This study was randomized, placebo－controlled, double－blind cross over design.Healthy adult Japanese, consisting of 20 non－flushers and 11 flushers, drank alcohol（0.4 g／kg body weight）between 2 and 2.5 hours before daily bedtime. Thirty minutes after finishing drinking, they ingested placebo or 800 mg of LOLA. At daily bedtime, they answered a drunkenness questionnaire. The next morning, they completed the Oguri－Shirakawa－Azumi sleep inventory, MA version（OSA－MA）and Visual Analog Scale（VAS）of mood when they woke up. Results　There were no significant differences between LOLA and placebo in any of the typical feelings evoked at night after drinking or the subjective feelings when they woke up the next morning. However, when non－flushers and flushers were analyzed separately, ingestion of LOLA significantly improved“Initiation and maintenance of sleep”in the OSA－MA, and “Feeling of fatigue”and“Sleeping contentment”in the VAS in flushers, but not in nonflushers. Conclusions　Taking 800 mg of LOLA after drinking alcohol may improve the quality of sleep and therefore produce a better mood state when awakened in the morning in flushers.