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難治性中枢性疼痛への Pregabalin の有用性
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JPY
Abstract
A 64-year-old man had thalamic hemorrhage on the right side since the age of 50. In addition to left hemiparesis, he had been experiencing sharp excruciating pain in the left side of his body, including his face. The pain was refractory to various analgesics. Although he had undergone motor cortex stimulation therapy at the age of 53, his pain was poorly controlled. Therefore, he was concomitantly administered anticonvulsant and antipsychotic drugs. However, because the pain was refractory to the drugs, he experienced severe anxiety, depression, and mental restlessness. Therefore, concomitant pregabalin was initiated at a low dose, and the dose was gradually increased. Eventually, his pain relieved, mental state stabilized, and nocturnal sleep improved, and he made positive efforts towards rehabilitation. Simultaneous pregabalin administration may be useful for treating central pain as well as diabetic neuropathic pain and postherpetic neuralgia when other therapeutic methods are unsuccessful.
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