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薬理と治療
- Authors: Kazuya Ooi1, et.al.
Abstract
Objective If a patch preparation(e. g., lidocaine tape or transdermal fentanyl patch)is to be applied on a dry area of a patient’s skin, drug permeability will be low and the expected drug effect may not be obtained. Hence, when a patch preparation is to be applied on a dry skin area, it is necessary to improve skin dryness by hydration. The purpose of this study is to clarify the optimal conditions for use of the hydration patch, Win Back, on human skin. Methods To examine the hydration effect of this hydration patch on the stratum corneum (SC), we measured the conductance on time-dependent changes of six healthy Japanese volunteers whose lower arm was applied with a hydration patch in comparison with ADOFEED Pap, a general poultice, and NIVEA Body Skin Milk, a skin cream. A tape stripping test was performed to investigate disruption of the SC by the test patches(hydration patch and poultice).Results The conductance level of the hydration patch after 30 min exposure was 4.3 times larger than that of the skin cream and 1.6 times larger than that of the poultice. Tape stripping caused few exfoliated SC cells following 30 min immersion with the patch. The hydration patch effectively hydrated the SC, requiring only 30 min for hydration, with few disruptions of the SC by tape stripping. Conclusion Clinical application of the hydration patch is easy and hygienic, making it appropriate for use with patch preparations on dry skin.
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