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薬理と治療
Abstract
Objectives We examined the effects of administration of unicellular green algae Chlorella on human serum lipid levels. Methods Thirty subjects(22 males and 8 females, 49.8±11.9 years)received one 9-g Chlorella tablet daily for 3 months. Serum total cholesterol(TC), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C)and triglycerides(TG)were evaluated before and after the administration period. These data were evaluated in all subjects. Moreover, TC, LDL-C and TG data were respectively evaluated after dividing subjects into two groups with regard to each measure;namely, normal groups consisting of the subjects whose baseline serum lipid levels had been less than the cutoff for dyslipidemia(TC 220 mg/dL, LDL-C 140 mg/dL and TG 150 mg/dL, JAS guidelines for prevention of atherosclerotic cardiovascular diseases)and high-value groups consisting of the others. Results TC and LDL-C levels in all subjects significantly decreased after the administration of Chlorella(p<0.05). HDL-C and TG levels did not significantly change. The change in TC levels between pre- and post-administration in the TC-high-value group(n=7)was significantly larger than that in the TC-normal group(n=23, p=0.036). The change in LDL-C levels in the LDL-C-high-value group(n=6)was also larger than that in the LDL-C-normal group(n=24). TG levels in the TG-high-value group(n=5)tended to decrease after the administration. The change in TG levels between pre- and post-administration in the TG-high-value group was significantly larger than that in the TG-normal group(n=25, p=0.035). Conclusion These results suggested that the administration of Chlorella was useful for management of serum lipid levels in humans.
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