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薬理と治療
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Abstract
Background/Objectives Diacylglycerol(DAG)oil was reported to have an anti-obesity effect and safety by long-term intake in healthy subjects. The objective of this study was to investigate the safety on high dose intake of dietary DAG oil with reduced glycidol fatty acid esters in healthy subjects. Methods A randomized, double-blind controlled, parallel study was coducted in 39 healthy subjects. The subjects ingested mayonnaise containing 30 g of DAG oil or TAG oil with same fatty acid composition at meal per day for 4 weeks. The subjects were instructed to consume either the mayonnaise containing of DAG oil or TAG oil all at once as often as possible. All subjects were received the clinical examination, physical examination, and medical examination/history taking at intervals of two weeks. Results No adverse effects originating in DAG oil or TAG oil were observed in the clinical examination, physical examination, and medical examination/history taking. Conclusions These results suggest that the safety on high dose intake of dietary DAG oil with reduced glycidol fatty acid esters in healthy subjects.
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