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A 13-week Feeding, Subchronic Toxicity Study of Maltosyl Cyclodextrin Mixture(ISOELEAT) in Crl: CD(SD)Rats
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JPY
Abstract
Maltosyl Cyclodextrin Mixture(ISOELEAT)is a hydrolyzed derivative of starch that is used as a food additive to make flavours stable. To evaluate the subchronic toxicity, ISOELEAT was administered dietary to male and female Crl:CD(SD)rats for 13 weeks at dose levels of 0(control), 2.5 and 5.0% in the diet. No deaths occurred and no toxic changes were noted in the clinical signs, body weight, food consumption, ophthalmology, urinalysis, hematology, blood biochemistry, organ weight or gross and histopathology. Thus, the no observed adverse effect level(NOAEL)of ISOELEAT was concluded to be more than 5.0% in the diet (2851.7 mg/kg/day for males and 3280.7 mg/kg/day for females)under conditions in the present study.
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