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薬理と治療
Abstract
Background Parkinson’s disease(hereinafter, PD)is a degenerative disease indicated by extrapyramidal signs, and characterized by degeneration of the substantia nigra dopamine nerve cells. In Japanese traditional medicine(called Kampo medicine), symptoms causing aging unsuitable for a particular age and a decline in body functions are believed to be symptoms of‘Jinkyo’(kidney deficiency). The purpose of this research was to investigate the efficacy of hachimijiogan and rokumigan, the representative medicines prescribed for Jinkyo, towards the onset and advancement of PD in model mouse. Methods Hachimijiogan and rokumigan were administered to rotenone-induced PD model mice, and the efficacy thereof was evaluated from the motor activity and drop in substantia nigra dopamine nerve cells. Furthermore, in order to investigate the action mechanism thereof, the 8-OH-dG in urine, which is the oxidative stress marker, was measured. Results A declined motor activity, reduced substantia nigra dopamine nerve cells, and increased 8-OH-dG concentration in urine were observed in PD model mice;however, these were significantly suppressed due to the administration of hachimijiogan. On the other hand, the significant effect did not observed by the administration of rokumigan. Conclusions From the above results, it was suggested that hachimijiogan could restrain the increase in oxidation stress as one of its action mechanisms, and include a suppressing effect against the onset and advancement of PD.
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