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薬理と治療
Abstract
Objectives In order to examine the effects of hot-water extract of Chlorella on mental fatigue in healthy volunteers, a randomized, placebo-controlled double-blind parallel group study was conducted. Methods Thirty three subjects(21 males and 12 females, 52.2±6.6 years)were received 2 placebo drinks or 2 test drinks daily for 8 weeks. Test drink contained 14.4 mL of hotwater extract of Chlorella. As a fatigue-inducing task, subjects performed Kraepelin’s arithmetic test(KAT)before and after the administration period. Evaluation of the subjective sensation of fatigue by profile of mood state(POMS)questionnaire, and determination of the concentrations of saliva cortisol, urine vanillylmandelic acid(VMA)and urine homovanillic acid(HVA)as biochemical markers for mental stress and fatigue were performed at pre- and post-KAT. Results The increase in the POMS fatigue score by KAT significantly decreased after the administration period compared with the start in test group(T-gr., p=0.002), but did not decrease in control group(C-gr.). Although, the increase in saliva cortisol concentration by KAT significantly increased after the administration period in both C-gr. and T-gr.(p<0.001), those in urine VMA and HVA concentrations significantly increased only in the C-gr. (p=0.022, 0.025). Urine VMA and HVA concentrations also significantly increased post-KAT compared with pre-KAT at the end of the administration period in C-gr(p<0.05), but did not significantly increase in T-Gr. Conclusion These results suggest that the administration of hot-water extract of Chlorella might be useful for attenuation of acute mental fatigue.
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