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高齢者におけるシロスタゾール投与時の心拍数に与える併用薬の影響に関する研究
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JPY
Abstract
Cilostazol is used widely as antiplatelet agents. However, the tolerability is decreased for typical side effects caused by its action mechanism. In our hospital, Mie Heart Center, the discontinuation rate of cilostazol treatment due to palpitation or tachycardia was higher in the geriatric patient group than it in the non-geriatric patient group. In the combined treatment with diltiazem hydrochloride which has effect of lowering the heart rate, a trend to decrease in heart rate was shown in the geriatric patient group from a month later. But there was no significant difference. In the combined treatment with beta-blockers, no significant changes in heart rate was shown at early term in both groups, and significant elevated heart rate(P<0.05)was shown only in the geriatric patient group after 1 month to 12 months in comparison with early term. We concluded that it is important to check the heart rate for particularly geriatric patients in case of cilostazol treatment.
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