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薬理と治療
Abstract
Objectives Effects of Lipoless, functional food, on energy expenditure in humans and lipid metabolism in rats after exercise were investigated. Methods 1)We conducted a crossover study in 11 healthy volunteers with a 7-days washout period. The participants were administered Lipoless after a meal, twice in the evening and morning, and loaded with an exercise of a bicycle ergometer. The change of sympathetic nerve activity was evaluated by detecting of heart rate variability. Energy expenditure was assessed by indirect calorimetry for 24 h. 2)Male rats were divided into the following 4 groups:Sedentary Control group, Exercise Control group, Sedentary Lipoless group, and Exercise Lipoless group. Lipoless were administered with 2% Lipoless containing diets, and a running exercise was loaded by a treadmill five times a week for 6 weeks of the experimental period. Results 1)Sympathetic nerve activity was enhanced after each meal, and energy expenditure after eating breakfast was significantly higher in Lipoless supplemented group than control group. Exercise had little effect on these changes. 2)Compared with the Sedentary Control group, in all other groups the visceral fat was decreased. A tendency of increase in muscular citrate synthase(CS)activity in the Sedentary Lipoless group, significant increase of CS and 3-hydroxyacyl-CoA dehydrogenase(3-HAD)activities in the Exercise Control group, and CS, 3-HAD, isocitrate dehydrogenase activities in the Exercise Lipoless group were observed compared with the Sedentary Control group. Futhermore, in the Exercise Lipoless group, the body weight gain was less than in the Sedentary Control group. Conclusion These results indicate that Lipoless might be useful food in the prevention of obesity on energy expenditure in short-term intake and on lipid metabolism for long-term.
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