薬理と治療

Abstract

Objective Effects of collagen peptide ingestion on healing of skin wound were examined in a rat model of pressure ulcer in comparison with effects of arginine known as a good ingredient. Methods SD rats aged 8 weeks were fed a low protein diet(AIN-93M;10% protein), and pressure ulcers were experimentally induced at 9 weeks of age. 0.2 g/kg/day collagen peptide, or 0.1 or 0.2 g/kg/day arginine was administered twice a day, half of a total daily dose each time. Healing process was compared among the control group and the experimental groups with regard to the daily wound area ratio, sum of daily wound area ratio, time and ratio of healing of pressure ulcer, and biochemical markers of blood. Results Wound area ratio was significantly smaller in the collagen peptide group and the arginine groups compared with the control group. Sum of daily wound area ratio was significantly smaller in the collagen peptide group but not in the arginine groups. Time and ratio of healing was significantly smaller in the collagen peptide group and the 0.2 g/kg/day arginine group. Collagen peptide-derived hydroxyprolylglycine that promotes wound healing of the skin in blood was significantly higher in the collagen peptide group. Conclusions The ingestion of collagen peptide promotes healing of pressure ulcers with effectiveness similar to the ingestion of arginine. The action mechanism of collagen peptide may differ from that of arginine.