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薬理と治療
Abstract
Objectives Acotiamide hydrochloride hydrate(acotiamide)that enhances the gastrointestinal motility by inhibiting acetylcholinesterase activity is a new drug for the treatment of functional dyspepsia. We examined the influence of acotiamide on the antisecretory effect of acid suppressants (lansoprazole, famotidine and nizatidine) in histamine-induced gastric acid secretion. Methods A rat gastric fistula model was used for the measurement of gastric acid secretion. The gastric fistula was inserted into the forestomach and the rat was then placed in a Ballman cage. Histamine hydrochloride(8 mg/kg/h)was infused continuously through the tail vein and then the gastric juice dripped through the fistula was collected at 1 hour intervals. Lansoprazole(3 mg/kg, a proton pump inhibitor, PPI), famotidine(10 mg/kg, H2-blocker)or nizatidine(100 mg/kg, H2-blocker)was administered intraduodenally, and acotiamide(1, 10, and 100 mg/kg)was administered subcutaneously. Each sample of gastric juice up to 4 hours after administration of these drugs was titrated using an automatic titrator to the endpoint of pH 7.0. Total acid output was calculated from the gastric juice volume and acidity. Results Lansoprazole, famotidine, and nizatidine suppressed histamine-induced gastric acid secretion. Acotiamide at 100 mg/kg or lower had no influence on the antisecretory effect of these acid suppressants. Conclusions These results indicated that acotiamide does not influence the antisecretory effect of acid suppressants.
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