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薬理と治療
Abstract
Background In elderly people, Swallowing reflex is reduced with age, and aspiration is caused in many cases. Swallowing reflex is controlled by SP is synthesized in the sensory ganglia of the pharynx. By activating Transient Receptor Potential Vanilloid(TRPV), it has been reported to promote the synthesis and secretion of SP. In this study, we performed the clinical study in order to assess the effect of the functional ingredient of capsaicin that is one of the TRPV1 agonists in enhanced swallowing function for an index in saliva SP. Methods After obtaining approval from the Ethical Review Board of Kochi Medical School, a clinical study of the capsaicin film was performed to evaluate the association between each functional ingredient and its swallowing function increasing effect by saliva SP amount and sensory tests after oral ingestion. Results In the sensory tests, capsaicin film had acridity significantly compared with the placebo. The saliva SP amount in the placebo group increased temporarily due to swallowing stimulation after oral ingestion of the placebo film, but 30 minutes after the oral ingestion. capsaicin film provided an increase in the amount of saliva SP immediately after oral ingestion of the film, and showed a significantly higher value of saliva SP between 15 and 30 minutes after oral ingestion, as compared with that in the placebo group. Conclusion It was suggested that capsaicin film was likely to increase the amount of SP in saliva after oral ingestion and enhance swallowing function.
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