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経口摂取ヒアルロン酸による光老化へアレスマウスの皮膚状態の改善
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JPY
Abstract
Hyaluronic acid is one of the important skin components and plays a role of keeping good skin conditions. Because of its unique capability to bind water, hyaluronic acid has been recognized as cosmetics, and been commercially available as functional foods in recent years. In this study, we examined the effect of orally administrated hyaluronic acid on the skin condition by using photoaged model in hairless mice, which were made by long and chronic UV irradiation. Long-term UV irradiation decreased the moisture content and the amount of collagen, and decomposed hyaluronic acid into low molecular weight in the skin of photoaged model mice. Orally administrated hyaluronic acid significantly recovered the moisture content, increased the amount of collagen, and normalized depolymerization of hyaluronic acid in skin. These results suggest that orally administrated hyaluronic acid improved the UV-damaged skin.
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