薬理と治療

Abstract

ChondroHi900E has a daily dose of five active ingredients, tocopherol acetate 100 mg, red ginseng dry extract 300 mg(equivalent to 3000 mg red ginseng), sodium chondroitin sulfate 900 mg, nicotinamide 12 mg, and panthenol 20 mg, and is an over-the-counter drinkable preparation for improvement of excessive sensitivity to cold (hiesho). The usefulness of ChondroHi900E in improving hiesho was compared with that of placebo in a double-blind crossover study. Ten female patients(22-40 years old)with hiesho took ChondroHi900E or placebo in a crossover fashion. The temperature of the right hand loaded with cold water was measured by dermal thermography as an objective indicator. In addition, warmth of the body was evaluated as a subjective indicator. The results revealed that ChondroHi900E significantly improved the recovery of temperature of the right hand after cold water loading as compared to placebo. In addition, subjects reported feeling body warmth at a significantly higher frequency after the intake of ChondroHi900E than after placebo. The above results suggest that ChondroHi900E is useful for improving hiesho.