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薬理と治療
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Abstract
Objective The aim of this study was to evaluate the effectiveness of lactic bacteria-containing kimchi on the blood cholesterol level, defecation status, and skin conditions. Methods Thirteen subjects(6 males and 7 females)who had relatively higher serum total cholesterol level(229±17 mg/dL)were enrolled in an open-labeled study, in which selfassessed skin conditions and defecation status as well as blood biochemistry were evaluated following intake of lactic bacteria-containing kimchi for 8 weeks at a daily dose of 50 g. Results The consumption of test food for 8 weeks resulted in a slight reduction of total cholesterol levels with respect to all the subjects(by 2.8±13.4 mg/dL), while, in 5 subjects who had both total cholesterol and LDL-cholesterol levels higher than the guideline levels, the reduction was 11.4±9.9 mg/dL(P=0.062 by Student’s paired t-test). The skin conditions were significantly improved with respect to total satisfaction(at the 4th week), moist feeling(at the 4th week), and texture(at the 4th and 8th weeks)(P<0.05 for all the parameters by Wilcoxon signed-rank test). Significant improvements were also observed with defecation status with respect stool frequency and strain at stool(P<0.05 for both parameters by Wilcoxon signed-rank test).Conclusions The consumption of lactic bacteria-containing kimchi is suggested to improve subjective quality of defecation and skin condition.
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