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薬理と治療
Abstract
Background Semi︱solid enteral nutrients are thought to help prevent aspiration pneumonia and diarrhea, because they are retained in the stomach better than the liquid enteral nutrients. Semi︱solid enteral nutrients are also physiologically egested from the stomach by peristaltic movement. However, it is unclear whether semi︱solid enteral nutrients affect the digestion and absorption of nutrient components. Objectives In this study, we investigated that nutritional usefulness of the semi︱solid enteral nutrient EN︱P0201 prepared by adding alginic acid and agar powder to the liquid enteral nutrient OSN︱001. Methods We administered EN︱P0201 or OSN︱001 to 8︱week︱old gastrostomized SD rats for 14 days. Then, we evaluated body weight gain, nitrogen balance, and fat absorption in gastrostomized rats. Results Rats receiving EN︱P0201 gained as much weight as rats receiving OSN︱001;no significant differences were observed in body weight gain and organ weight between the OSN︱001 group and the EN︱P0201 group. No significant differences were observed in nitrogen balance and biological value between the OSN︱001 group and the EN︱P0201 group. No significant differences were observed in serum TP, ALB and some minerals between the OSN︱001 group and the EN︱P0201 group. Conclusions These results suggest that the nutritional usefulness of EN︱P0201 is equivalent to that of OSN︱001.
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