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薬理と治療
Abstract
Background Constipation is a common disease which is frequent among the daily life. Several types of medicines are used for the treatment of constipation, including the Kampo medicine. Here we examined the effects of Junchoto(JCT), which is empirically prescribed in Japan for the treatment of chronic constipation, on constipation in rats and clarified the action mechanism. Methods JCT(300 and 1000 mg╱kg)was orally administered to normal and codeine phosphate ︱induced constipation model rats, and the defecation response was evaluated. The action of JCT on the chloride channel was also assayed. Results JCT dose︱dependently increased the number and dry weight of feces in both the normal and codeine phosphate︱induced constipation model rats. JCT also stimulated the secretion of fluid in the small intestine and accelerated the small bowel transit. The activity of cystic fibrosis transmembrane conductance regulator(CFTR), a chloride channel, was increased by the JCT treatment. Conclusion These results suggest that JCT improves constipation by increasing the secretion of fluid and transit in the small intestine, which may be mediated by the activation of CFTR in the intestinal apical cell membrane.
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