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Antihypertensive Effect of Quercetin Glycosides in Apocynum venetum L. Leaves
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JPY
Abstract
Objectives The leaves of Apocynum venetum L(. Apocynaceae), commonly known as Luobuma in China, are a traditional and popular Chinese herb with a long history of use as an antihypertensive tea in China and Japan. Hyperoside[HP]and isoquercitrin[IQ]are contained in A. venetum leaves in ratio of 1:1 as the principle quercetin glycosides. The dose-related decreases in blood pressure of HP, IQ and the equivalent mixture[HP+IQ]were examined in the doses of 10, 20, 40, and 80 mg╱kg, respectively. Methods HP, IQ and[HP+IQ]were given orally to Male SHR╱Izm rats by gavage for 7 weeks, respectively. Systolic blood pressure in each conscious rat was measured by the indirect tail-cuff method with an authomatic sphygmotonograph. Results The only[HP+IQ]in dose of 40 mg╱kg showed a significant reduction in blood pressure in SHR, which showed an inverted U-shaped dose-dependent relationship. Conclusions The content of[HP+IQ]in an adequate and restricted dose might be required in order to produce the antihypertensive effect of A. venetum leaves since the antihypertensive effect of[HP+IQ]showed an inverted U-shaped dose-dependent relationship.
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