薬理と治療

Abstract

Objecive Blueberries contain a lot anthocyanin, and have been considered healthful for eyesight. In the present study, palliative effect of standard alcoholic bilberry extract（SBE）was investigated on accommodative asthenopia compulsory induced by video display terminal （VDT）stress. Methods Placebo-controlled double-blind randomized clinical trial was conducted in 30 Japanese healthy adults（range：20-59 years old）. Volunteers took 160 mg of SBE or placebo daily for 4 weeks. On the first and the last day of the administration, objective and subjective examinations were performed three times：before, prompt after, and 20 minutes after VDT work. They played Tetris game for a half hour on iPhone as deemed VDT work. Accommodation was examined by using TriIRIS(R) C9000. Subjective symptoms were evaluated by means of questionnaire sheet. Results Accommodative function was significantly improved in SBE group compared with controls at 20 minutes after VDT work（P＜0.05）. Subjective complaints of eyestrain were also restorative both before（P＜0.05）and 20 minutes after（P＜0.01）VDT task among SBE users compared with controls. Conclusions Oral intake of qualified SBE saved eyestrain both objectively and subjectively when abusing eyes. It suggests that SBE may reduce eye fatigue caused by computers and smartphones.